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Arachidonic acid; Cholesterol esters; Fatty acids; Genotype; Hepatocytes; Lipogenesis; Non-alcoholic fatty liver disease; Phosphatidylcholines; Transmembrane 6 superfamily member 2; Triglycerides
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
BACKGROUND: Carriers of the transmembrane 6 superfamily member 2 E167K gene variant (TM6SF2EK/KK) have decreased expression of the TM6SF2 gene and increased risk of NAFLD and NASH. Unlike common 'obese/metabolic' NAFLD, these subjects lack …