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Small Interfering/administration & dosage; Stromal Interaction Molecule 1/genetics; Thyroid Epithelial Cells/drug effects/pathology; Thyroid Gland/drug effects/pathology; Thyroid Neoplasms/drug therapy/genetics/pathology; Up-Regulation/drug effects/genetics; Young Adult; Zebrafish; Invasion; Migration; ORAI1 calcium channel; Proliferation; Store-operated calcium entry (SOCE); Stromal interaction molecule 1 (STIM1); Thyroid cancer
Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells
Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate stoperated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remain elusive. We show that …