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Steroid/genetics; Signal Transduction/genetics; Akt signaling; CRISPR-Cas9; Glycolysis; OSBP-related protein; OSBPL2; Triacylglycerol
OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism
ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)-lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell …