Tumor; Cell Proliferation/drug effects/genetics; Female; G1 Phase/drug effects/genetics; Humans; Indoles/administration & dosage; Male; Middle Aged; Nanoparticles/administration & dosage; Neoplasm Proteins/genetics; ORAI1 Protein/genetics; Polymers/administration & dosage; RNA

Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells

Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate stoperated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remain elusive. We show that …