News
December 10th, 2024: Congratulations to Birong for successfully passing her PhD viva!
December 6th, 2024: Birong was selected to give a seminar at the EMBL-EBI-AstraZeneca workshop.
August 29th, 2024: Congratulations to Dien for successfully passing his PhD viva!
March 29th, 2024: Congratulations to Dien, who was selected to give a talk at the APASL 2024 annual meeting and won an Investigator Award.
March 1st, 2024: Congratulations to Wei for winning the European Association for the Study of Obesity Travel Grant and being selected to give a talk at the 31st European Congress on Obesity annual meeting.
November 27th, 2023: Dien’s review on Complement and NAFLD has been published in Liver International.
October 25th, 2023: Congratulations to Birong, who was selected as a finalist for the PGR Student Excellence Award for Innovation!
October 1st, 2023: Welcome to Luyang, who is joining the lab as a new PhD student.
September 25th, 2023: Congratulations to Birong, who was handpicked to attend the 2023 EASO Early Career Network Winter School, with full travel costs covered.
September 7th, 2023: Congratulations to Dien for winning the ECR award at the 29th International Compelment Workshop for his talk and abstract. Well done!
Research
The reason why the universe is eternal is that it does not live for itself; it gives life to others as it transforms.
- Lao Tzu (604 BC - 531 BC)
The scientific history of our world begins with observations of regularities in nature. Without Tycho’s meticulous record-keeping of 1,006 stars, Kepler would not have been able to come up with his three laws of planetary motion in the universe. In health research, we still await available and agreed notions of what underlying regularities exist. Recent advances in high-throughput technologies, along with the rapid deluge of biomedical information, enable us to think creatively about how to understand data, identify regularities, and ultimately leverage them to improve our health. In response to this challenge, the long-term research goal of our lab is to develop and apply innovative systems biology approaches for disease diagnostics and therapeutics. We are specifically interested in harnessing and integrating various types of omics, clinical, and molecular data to holistically understand disease onset and progression. We are particularly keen on developing computational methods/tools and using them in conjunction with biological approaches to gain a deeper understanding of metabolic inflammation. Our focus is on, but not limited to, fatty liver disease.
NASH treatment
Comprehensive computational repositioning of drug compounds for steatohepatitis
circular RNAs
Deep screening functional circRNAs for diagnostics and therapeutics
Recent Publications
Google Scholar
#: co-first author; *: Corresponding author
- M. Goepp, J.V. Milburn, B. Zhang, Y. Dong, V. Tyrrell, X. Zheng, J.M. Marshall, S. Bolsega, M. Basic, L. Glendinning, G.T. Ho, J. Satsangi, R.M. Breyer, S. Narumiya, H.J. McSorley, J.K.J. Schwarze, C.J. Anderson, D.H. Dockrell, A.G. Rossi, A. Bleich, C.D. Lucas, V.B. O’Donnell, D. Mole, M.J. Arends, Y. Zhou, C. Yao, Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis, Cell Host Microbe 33 (2025) 671-687 e676.
- S. Pauli, N. Oliveras-Canellas, J.M. Moreno-Navarrete, A. Castells-Nobau, F.J. Ortega, J.I. Rodriguez-Hermosa, E. Castro, B. Zhang, Y. Zhou, J. Gomez-Ambrosi, A.B. Crujeiras, O.A. Rangel-Zuniga, L. Garrido-Sanchez, S. Becerril, M. Pardo, J.L. Romero-Cabrera, C. Gutierrez-Repiso, M.C. Carreira, M. Macias-Gonzalez, M.A. Martinez-Olmos, G. Fruhbeck, L.M. Seoane, J. Lopez-Miranda, F.J. Tinahones, C. Dieguez, J. Mayneris-Perxachs, J.M. Fernandez-Real, Cellular composition and transcriptomics of subcutaneous adipose tissue linked to blood glycated haemoglobin, Eur J Clin Invest (2025) e70033.
- L. Zhou, J. Liu, P. Yao, X. Liu, F. Chen, Y. Chen, L. Zhou, C. Shen
*, Y. Zhou*, X. Du*, J. Hu*, Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma, J Transl Med 22 (2024) 1163. - V.D. Nguyen, T.R. Hughes, Y. Zhou, From complement to complosome in non-alcoholic fatty liver disease: When location matters, Liver Int 44 (2024) 316-329.
- B. Hu, Y. Yin, B. Zhang, S. Li, K. Li, Y. Zhou
*, Q. Huang*, Villin-1 regulates ferroptosis in colorectal cancer progression, FEBS J (2024).
People
We are growing! Reach out if you are interested in joining us.
Principal Investigator
Members
Alumni
Kayla Chan
Engineer at an internet company in London
Nick Hodson
Medical doctor at the St George hospital
Resources
Developed by YZ lab
Softwares
NASH App: An open-source data portal to overview the molecular landscape of Non-Alcoholic Steatohepatitis
Lipidomics Analysis Toolbox (Under going)
Documentations
Teaching Materials: Master Programme in Bioinformatics (Internal only) Personal Notes: Designing/updating this site (Internal only)