adiponutrin; lipase; lipid droplet; lipidomics; nonalcoholic fatty liver disease; patatin-like phospholipase domain containing 3

The I148M substitution in patatin-like phospholipase domain containing 3 (PNPLA3(I148M)) determines a genetic form of nonalcoholic fatty liver disease. To elucidate the mode of PNPLA3 action in human hepatocytes, we studied effects of WT PNPLA3 …