Animals; Cell Line; Genome

Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B

Hepatitis C virus (HCV) replication and pathogenesis involve both virus-encoded proteins and cellular factors. In our study, we showed that NS5B, the HCV RNA-dependent RNA polymerase, interacted with M2 type pyruvate kinase (M2PK) but not L type …