Ceramides; Dihydroceramides; Free fatty acids; Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; PNPLA3; Patatin-like phospholipase domain containing protein 3

BACKGROUND & AIMS: Recent data in mice have identified de novo ceramide synthesis as the key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in liver fat due to IR ('Metabolic NAFLD' but not that due to the I148M …