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EP receptors; Foxp3; Inflammation; Prostaglandin E2; Regulatory T cell; TGF-beta
Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-beta signalling
Regulatory T (Treg) cells are essential for control of inflammatory processes by suppressing effector T cell functions. The actions of PGE2 on the development and functif Treg cells, particularly under inflammatory conditions, are debated. In this …