Steroid/genetics/metabolism; Signal Transduction; CRISPR-Cas9; F-actin; OSBPL2; RNA sequencing; interactome

ORP2 is implicated in cholesterol transport, triglyceride metabolism, and adrenocortical steroid hormone production. We addressed ORP2 function in hepatocytes by generating ORP2-knockout (KO) HuH7 cells by CRISPR-Cas9 gene editing, followed by …