Viral; Hepacivirus/genetics/metabolism; Humans; Isoenzymes/metabolism; Mice; Pyruvate Kinase/genetics/metabolism; Replicon; Two-Hybrid System Techniques; Viral Nonstructural Proteins/metabolism

Hepatitis C virus (HCV) replication and pathogenesis involve both virus-encoded proteins and cellular factors. In our study, we showed that NS5B, the HCV RNA-dependent RNA polymerase, interacted with M2 type pyruvate kinase (M2PK) but not L type …